脂肪干细胞亚群的不同特性决定脂肪库的特定特征
2022-01-14   阅读:249   来源:细胞

韩国首尔国立大学Jae Bum Kim、浦项科技大学Jong Kyoung Kim等研究人员合作发现,脂肪干细胞亚群的不同特性决定脂肪库的特定特征。该研究于2022年1月11日在线发表于国际一流学术期刊《细胞—代谢》。

研究人员表示,在哺乳动物中,白色脂肪组织主要分为内脏附睾脂肪组织(EAT)和皮下腹股沟脂肪组织(IAT),其具有不同的代谢特性。尽管新的证据表明,脂肪干细胞(ASC)的亚群对解释脂肪库的差异很重要,但两个脂肪库的ASC还没有被比较研究过。

研究人员报道了异质性ASC的特征,并研究了内在和组织微环境因素对不同ASC特征的影响。研究人员证明EAT和IAT的ASC亚群在三个脂肪生成阶段表现出不同的分子特征。ASC的移植实验显示,ASC的内在特征主要决定了它们的脂肪生成潜力。在致肥刺激下,EAT特异性SDC1ASC促进纤维化重塑,而IAT特异性CXCL14ASC则抑制巨噬细胞的浸润。此外,IAT特异性BST2高的ASC表现出成为米色脂肪细胞的高潜力。总的来说,这些数据扩大了对ASC的理解,对白色脂肪库差异的起源有了新的认识。

附:英文原文

Title: Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics

Author: Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim

Issue&Volume: 2022-01-11

Abstract: In mammals, white adipose tissues are largely divided into visceral epididymal adiposetissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolicproperties. Although emerging evidence suggests that subpopulations of adipose stemcells (ASCs) would be important to explain fat depot differences, ASCs of two fatdepots have not been comparatively investigated. Here, we characterized heterogeneousASCs and examined the effects of intrinsic and tissue micro-environmental factorson distinct ASC features. We demonstrated that ASC subpopulations in EAT and IAT exhibiteddifferent molecular features with three adipogenic stages. ASC transplantation experimentsrevealed that intrinsic ASC features primarily determined their adipogenic potential.Upon obesogenic stimuli, EAT-specific SDC1+ ASCs promoted fibrotic remodeling, whereas IAT-specific CXCL14+ ASCs suppressed macrophage infiltration. Moreover, IAT-specific BST2high ASCs exhibited a high potential to become beige adipocytes. Collectively, our databroaden the understanding of ASCs with new insights into the origin of white fat depotdifferences.

DOI: 10.1016/j.cmet.2021.11.014

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